- 2-Methoxycinnamic acid
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- $0.00 / 25KG
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2025-08-08
- CAS:6099-03-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- 2-Methoxycinnamic acid
-
- $0.00 / 25KG
-
2025-06-27
- CAS:6099-03-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 2-Methoxycinnamic acid Basic information |
| | 2-Methoxycinnamic acid Chemical Properties |
| Melting point | 182-186 °C | | Boiling point | 250.41°C (rough estimate) | | density | 1.1479 (rough estimate) | | refractive index | 1.5088 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | pka | pK1:4.462 (25°C) | | color | White | | BRN | 2209714 | | InChI | InChI=1S/C10H10O3/c1-13-9-5-3-2-4-8(9)6-7-10(11)12/h2-7H,1H3,(H,11,12) | | InChIKey | FEGVSPGUHMGGBO-UHFFFAOYSA-N | | SMILES | C(O)(=O)C=CC1=CC=CC=C1OC | | LogP | 2.418 (est) | | CAS DataBase Reference | 6099-03-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Propenoic acid, 3-(2-methoxyphenyl)-(6099-03-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29189900 |
| | 2-Methoxycinnamic acid Usage And Synthesis |
| Chemical Properties | light yellow crystalline powder | | Uses | (E)-3-(2-Methoxyphenyl)acrylic Acid is a noncompetitive inhibitor of tyrosinase. | | Definition | ChEBI: (E)-2-methoxycinnamic acid is a member of the class of cinnamic acids that is trans-cinnamic acid carrying a methoxy substituent at position 2 on the benzene ring. It has a role as a Brassica napus metabolite and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a member of cinnamic acids and a monomethoxybenzene. It is functionally related to a trans-cinnamic acid. | | Synthesis | To a 500 mL three-necked round-bottomed flask was added o-methoxybenzaldehyde (20 g, 146.90 mmol, 1.00 eq.), pyridine (250 mL), malonic acid (18.3 g, 175.86 mmol, 1.20 eq.) and piperidine (2.5 g, 29.36 mmol, 0.20 eq.). The reaction mixture was stirred at 85°C overnight. Upon completion of the reaction, most of the solvent was removed by distillation under reduced pressure, followed by adjusting the pH of the remaining solution with aqueous hydrochloric acid to 3.0. The precipitated solid was collected by filtration to afford 25.6 g (98% yield) of 2-methoxycinnamic acid as a white solid. | | References | [1] Patent: WO2014/182950, 2014, A1. Location in patent: Paragraph 00322; 00323
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 336 - 343
[3] Journal of the Indian Chemical Society, 1988, vol. 65, # 3, p. 187 - 191
[4] Molecules, 2009, vol. 14, # 10, p. 4166 - 4179
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 15, p. 4513 - 4519 |
| | 2-Methoxycinnamic acid Preparation Products And Raw materials |
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