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| | Amodiaquin dihydrochloride dihydrate Basic information |
| Product Name: | Amodiaquin dihydrochloride dihydrate | | Synonyms: | Amodiaquine hydrochloride USP24;AMODIAQUINE 2HCL DIHYDRATE;AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE;AMODIAQUIN DIHYDROCHLORIDE;amodiaquin dihydrochloride dihydrate;AMODIAQUINE DIHYDROCHLORIDE;AMODIAQUIN HYDROCHLORIDE;4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE | | CAS: | 6398-98-7 | | MF: | C20H25Cl2N3O2 | | MW: | 410.34 | | EINECS: | 642-210-0 | | Product Categories: | CAMOQUIN | | Mol File: | 6398-98-7.mol |  |
| | Amodiaquin dihydrochloride dihydrate Chemical Properties |
| RTECS | GO7300100 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO or methanol | | form | Solid | | color | White to Yellow to Orange | | λmax | 342nm(MeOH)(lit.) | | Merck | 14,572 | | Stability: | Hygroscopic | | Major Application | forensics and toxicology
pharmaceutical (small molecule) | | InChI | InChI=1S/C20H22ClN3O.ClH.H2O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);1H;1H2 | | InChIKey | AOFIMJMWPZOPAJ-UHFFFAOYSA-N | | SMILES | N(C1C=CC(O)=C(CN(CC)CC)C=1)C1=CC=NC2=CC(Cl)=CC=C12.Cl.O | | CAS DataBase Reference | 6398-98-7(CAS DataBase Reference) |
| WGK Germany | 3 | | HS Code | 2933492250 | | Storage Class | 11 - Combustible Solids |
| | Amodiaquin dihydrochloride dihydrate Usage And Synthesis |
| Chemical Properties | Light yellow powder | | Uses | antimalarial | | Uses | An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor | | Brand name | Camoquin (Parke-Davis). | | Biological Activity | Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent. | | in vivo | In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation. | | IC 50 | Plasmodium; Nurr1/NR4A2 |
| | Amodiaquin dihydrochloride dihydrate Preparation Products And Raw materials |
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