唑来磷酸一水化合物
| 中文名称 | 唑来磷酸一水化合物 |
|---|---|
| 中文同义词 | 1-羟基-2-(咪唑-1-基)-亚乙基-1,1-二磷酸一水化物;唑来磷酸一水化合物;唑来磷酸,一水合物;唑来磷酸一水合物, 骨吸收抑制剂;唑来膦酸单水合物;唑来磷酸(标准品);唑来磷酸一水化合物(唑来膦酸一水化合物、唑仑膦酸一水化合物);唑来磷酸一水化合物(CAS号:165800-06-6) |
| 英文名称 | Zoledronic acid hydrate |
| 英文同义词 | [1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACID MONOHYDRATE;(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid hydrate;(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid monohydrate;PHOSPHONIC ACID, [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE]BIS-, MONOHYDRATE;zoledronic acid hydrate;ZoledronicacidforInjection;[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate |
| CAS号 | 165800-06-6 |
| 分子式 | C5H10N2O7P2.H2O |
| 分子量 | 290.11 |
| EINECS号 | |
| 相关类别 | 医药原料;膦配体;有机磷;医药 高钙血;咪唑;Other APIs;原料药;抗肿瘤;Smad;TGF-beta;11;医用原料 |
| Mol文件 | 165800-06-6.mol |
| 结构式 |  |
唑来磷酸一水化合物 性质
| 熔点 | 245 °C(dec.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O：≥2mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: ≥2mg/mL |
| Merck | 14,10187 |
| InChI | InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2 |
| InChIKey | FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| SMILES | C(O)(CN1C=NC=C1)(P(O)(O)=O)P(O)(O)=O.O |
| CAS 数据库 | 165800-06-6(CAS DataBase Reference) |
| Target | Value |
|
Ras
() | |
|
Rho
() |
Zoledronic Acid monohydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.
Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.
Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.
Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) induces apoptosis in MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis.
Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM.
Cell Viability Assay
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 1 day, 3 days, 5 days, 7 days |
| Result: | Reduced cells viability at 10 µM and 100 µM. |
Apoptosis Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 1 days, 4 days, 7 days |
| Result: | Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations). |
Western Blot Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 4 days |
| Result: | Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 µM. |
Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.
Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.
| Animal Model: | Five-week-old C57BL6 mice |
| Dosage: | 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg |
| Administration: | Intraperitoneal injection, weekly, for 3 weeks |
| Result: | Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg. |
118072-93-8
165800-06-6
以(1-羟基-2-(1H-咪唑-1-基)乙烷-1,1-二基)二膦酸为原料合成1-羟基-2-(1-咪唑基)乙烷-1,1-二磷酸水合物的一般步骤如下： 实施例3：唑来膦酸一水合物的制备 将根据实施例1获得的原始潮湿唑来膦酸（相当于90.3g粗产物）悬浮于3050ml水中。在搅拌条件下，将悬浮液加热至回流状态。随后，加入EPO水使总体积达到3750ml，直至完全溶解。停止加热，继续搅拌，使溶液缓慢冷却至室温。当内部温度降至约70-80℃时，进一步冷却至2-5℃，并在此温度下维持1小时。过滤沉淀，并用冰水洗涤。将所得沉淀置于气流烘箱中干燥。最终，在5°C至60°C条件下获得169.3g（产率89%）无色晶体。通过热重分析（TGA）测得结晶水损失为6.8%，证实为一水合物。该物质的X射线粉末衍射（XRPD）图谱在2θ值为12.1°、12.8°、15.7°、18.9°±0.2°处显示特征峰，与已知晶型I（US 2005/0054616）的衍射数据一致。图1A展示了其XRPD图谱，图IV则展示了晶胞中原子的排列结构。
参考文献：
[1] Patent: WO2007/16982, 2007, A1. Location in patent: Page/Page column 7-8
[2] Patent: EP1925621, 2008, A1. Location in patent: Page/Page column 14
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | 46621 | 唑来磷酸 Zoledronic acid monohydrate | 165800-06-6 | 5g | 2040元 |
| 2026/07/06 | S5244 | 唑来磷酸一水化合物 Zoledronic acid monohydrate | 165800-06-6 | 25mg | 795.17元 |