3-AMINO-5-BROMO-2-NITROPYRIDINE manufacturers
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| | 3-AMINO-5-BROMO-2-NITROPYRIDINE Basic information |
| Product Name: | 3-AMINO-5-BROMO-2-NITROPYRIDINE | | Synonyms: | 3-AMINO-5-BROMO-2-NITROPYRIDINE;5-Bromo-2-nitro-pyridin-3-ylamine;5-BroMo-2-nitro-3-pyridinaMine;5-BroMo-2-nitropyridin-3-aMine;3-Pyridinamine, 5-bromo-2-nitro- | | CAS: | 433226-05-2 | | MF: | C5H4BrN3O2 | | MW: | 218.01 | | EINECS: | | | Product Categories: | | | Mol File: | 433226-05-2.mol |  |
| | 3-AMINO-5-BROMO-2-NITROPYRIDINE Chemical Properties |
| Boiling point | 404.0±40.0 °C(Predicted) | | density | 1.929±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -3.55±0.25(Predicted) | | form | powder | | color | Very dark yellow | | InChI | InChI=1S/C5H4BrN3O2/c6-3-1-4(7)5(8-2-3)9(10)11/h1-2H,7H2 | | InChIKey | GOXZJSIRAHNQQG-UHFFFAOYSA-N | | SMILES | C1([N+]([O-])=O)=NC=C(Br)C=C1N |
| | 3-AMINO-5-BROMO-2-NITROPYRIDINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-amino-5-bromo-2-nitropyridine from ethyl (5-bromo-2-nitropyridin-3-yl)carbamate: to a solution of ethyl (5-bromo-2-nitropyridin-3-yl)carbamate (1.5 g, 5.2 mmol) in tetrahydrofuran (10 ml) was added a solution of potassium hydroxide (582 mg, 10.4 mmol) in water (5.0 ml) solution and the reaction mixture was stirred at 90°C overnight. After completion of the reaction, water was added to the mixture and precipitate was precipitated, the precipitate was collected by filtration, washed with water and then dried under reduced pressure to give 3-amino-5-bromo-2-nitropyridine (1.1 g, 95% yield). | | References | [1] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0226; 0231; 0232
[2] Patent: US2004/82583, 2004, A1
[3] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 82; 83
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5913 - 5917
[5] Patent: WO2017/7756, 2017, A1. Location in patent: Paragraph 224 |
| | 3-AMINO-5-BROMO-2-NITROPYRIDINE Preparation Products And Raw materials |
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