- 2-ETHYNYLBENZALDEHYDE
-
- $6.60 / 1KG
-
2019-12-26
- CAS:38846-64-9
- Min. Order: 1KG
- Purity: 97%-99%
- Supply Ability: 1-1000kg
|
| | 2-ETHYNYLBENZALDEHYDE Basic information |
| | 2-ETHYNYLBENZALDEHYDE Chemical Properties |
| Melting point | 64-67 °C (lit.) | | Boiling point | 115 °C(Press: 12 Torr) | | density | 1.07±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | solid | | color | Light yellow to light brown | | InChI | 1S/C9H6O/c1-2-8-5-3-4-6-9(8)7-10/h1,3-7H | | InChIKey | ZEDSAJWVTKUHHK-UHFFFAOYSA-N | | SMILES | [H]C(=O)c1ccccc1C#C |
| Hazard Codes | Xi,F | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2912290090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-ETHYNYLBENZALDEHYDE Usage And Synthesis |
| Uses | 2-Ethynylbenzaldehyde may be used in the synthesis of the following:
- iodoisoquinoline-fused benzimidazoles obtained via tandem iodocyclization of 2-ethynylbenzaldehyde with o-benzenediamine and iodine in the presence of copper(I)iodide
- N-[(7,7a-dihydroisoquinolino[2,1-a]perimidin-13-yl)methyl]-N-isopropylpropan-2-amine obtained via a multi-step process
It may also be used in the synthesis of the following substituted 2-alkynylbenzaldehydes by Sonogashira coupling:
- 2-[(2-bromophenyl)ethynyl]benzaldehyde
- 2-[(2-bromo-5-fluorophenyl)ethynyl]benzaldehyde
- 2-[(2-bromo-5-methylphenyl)ethynyl]benzaldehyde
- 2-(phenylethynyl)benzaldehyde
- 2-[(4-methylphenyl)ethynyl]benzaldehyde
| | Synthesis | General procedure for the synthesis of 2-ethynylbenzaldehyde from 2-[(trimethylmethylsilyl)ethynyl]benzaldehyde: 2-[(trimethylmethylsilyl)ethynyl]benzaldehyde (1 mmol), an inorganic base (potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylmethylsilyl, sodium trimethylmethylsilyl, 0.05 mmol), and 2 mL of DMA or DMSO solvent were added to a 10mL sealed tube. The mixture was placed in an oil bath at 60 °C and the reaction was stirred for 12 h. The progress of the reaction was monitored by TLC. Upon completion of the reaction, equal amounts of homotrimethylbenzene or n-undecane were added as an internal standard for the crude product, and the exact yield of the product was determined by GC and GC-MS analysis. According to the results of GC and GC-MS analyses, when DMSO was used as the reaction solvent and potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylmethylsilyl, sodium trimethylmethylsilyl were used as catalysts, the yields of the products were 44%, 47%, 49%, 50%, 77%, and 70% respectively. When DMA was used as the reaction solvent with the same inorganic base as the catalyst, the yields of the products were 40%, 42%, 42%, 40%, 61%, 59%, respectively. | | References | [1] Synthesis, 2010, # 14, p. 2367 - 2378
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 11, p. 1425 - 1433
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, p. 2321 - 2332
[4] Advanced Synthesis and Catalysis, 2011, vol. 353, # 2-3, p. 392 - 400
[5] Journal of the American Chemical Society, 2015, vol. 137, # 9, p. 3233 - 3236 |
| | 2-ETHYNYLBENZALDEHYDE Preparation Products And Raw materials |
|