5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) manufacturers
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| | 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) Basic information |
| | 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) Chemical Properties |
| Boiling point | 279.1±42.0 °C(Predicted) | | density | 1.359±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.90±0.10(Predicted) | | form | solid | | color | Light yellow |
| | 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine a25: Aminothiourea a24 (40 g, 0.44 mol, 1 eq.) was suspended in dioxane (400 mL) at room temperature, followed by a one-time addition of methoxyacetic acid (39.56 g, 0.44 mol, 1 eq.). The reaction mixture was heated to 80 °C and phosphorus trichloride (67.54 g, 0.44 mol, 1 eq.) was added slowly and dropwise over 1.5 hours. After completion of the reaction (4 h), water was added and the solution was neutralized to pH 6-7 using sodium hydroxide pellets. after extraction with EtOAc/iPrOH (9/1) mixed solvent, the solvent was evaporated in vacuum and the residue was recrystallized by MeTHF/iPrOH mixed solvent to afford pure 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine a25 (51 g, yield 81%).LC-MS (MH+): 146. | | References | [1] Patent: WO2011/47860, 2011, A1. Location in patent: Page/Page column 25
[2] Patent: US4090026, 1978, A |
| | 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) Preparation Products And Raw materials |
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