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| | 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Basic information |
| | 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Chemical Properties |
| Boiling point | 253.5±32.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.22±0.10(Predicted) | | Appearance | Colorless to off-white Solid-Liquid Mixture |
| | 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Usage And Synthesis |
| Synthesis | 1.6 M n-butyllithium (0.9 mL, 1.4 mmol) was added slowly and dropwise to a tetrahydrofuran (THF, 10 mL) solution of 1-methyl-1H-1,2,3-triazole (32.0 mg, 1.2 mmol) at -78 °C, ensuring that the reaction temperature was maintained below -60 °C. After the reaction mixture was stirred continuously at -78 °C for 30 min, N,N-dimethylformamide (0.14 mL, 1.8 mmol) was added. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (3 × 10 mL). The organic phases were combined, washed with water (3 x 10 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of 95:5 to 100:0 dichloromethane to methanol, resulting in 1-methyl-1H-1,2,3-triazole-5-carboxaldehyde as a yellow oil (40 mg, 30% yield).1H NMR (CDCl3) data: δ 4.10 (s, 3H), 7.88 (s, 1H), 9.55 (s, 1H). 1H). | | References | [1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 650 - 654
[2] Patent: WO2008/135826, 2008, A2. Location in patent: Page/Page column 157; 158
[3] Patent: US2014/107094, 2014, A1. Location in patent: Paragraph 0625; 0626
[4] Patent: US2015/105372, 2015, A1. Location in patent: Paragraph 0304; 0305
[5] Patent: WO2015/57206, 2015, A1. Location in patent: Page/Page column 74; 75 |
| | 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Preparation Products And Raw materials |
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