ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

Request For Quotation
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Necrostatin 2
CAS:852391-19-6
Purity:98.00% Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Necrostatin 2 R-isomer
CAS:852391-19-6
Purity:98% Package:10mg Remarks:V3292
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:Necrostatin 2
CAS:852391-19-6
Purity:99.92% Package:2mg;78USD|5mg;166USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:Necrostatin 2
CAS:852391-19-6
Purity:99% Package:$54.9/1mg;$140.9/5mg;$241.9/10mg;$543.9/50mg;Bulk package Remarks:99%
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Necrostatin 2
CAS:852391-19-6
Purity:99.31% Package:2mg;83USD|5mg;137USD

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- manufacturers

  • Necrostatin 2
  • Necrostatin 2 pictures
  • $83.00
  • 2026-04-23
  • CAS:852391-19-6
  • Purity: 99.31%
  • Supply Ability: 10g
  • Necrostatin 2
  • Necrostatin 2 pictures
  • $78.00
  • 2025-05-15
  • CAS:852391-19-6
  • Purity: 99.92%
  • Supply Ability: 10g
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Basic information
Product Name:2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
Synonyms:2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-;Necrostatin 2;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR;Necroptotic Inhibitor;Necrostatin 2 R-isomer;(±)-Necrostatin-2;5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione (5R)-
CAS:852391-19-6
MF:C13H12ClN3O2
MW:277.71
EINECS:
Product Categories:
Mol File:852391-19-6.mol
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Structure
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties
density 1.450±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka8.48±0.70(Predicted)
color White to light yellow
Safety Information
HS Code 2933998090
MSDS Information
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Usage And Synthesis
UsesNecrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.
Biological Activitynecrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro.
targetRIPK2
IC 50RIPK1
references[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40.
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials
Tag:2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-(852391-19-6) Related Product Information