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ChemPep, Inc. |
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+1 (888) 615-9178 / (561) 791-8787 |
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MPEG16-Propyne manufacturers
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| | MPEG16-Propyne Basic information |
| Product Name: | MPEG16-Propyne | | Synonyms: | MPEG16-Propyne;2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxatripentacont-52-yne;Propargyl PEG17 methane,PROTAC Linkers,inhibit,PropargylPEG17methane,Inhibitor,Propargyl-PEG-17-methane;mPEG16-Propyne/2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxatripentacont-52-yne;m-PEG16-propargyl | | CAS: | 2169967-47-7 | | MF: | C36H70O17 | | MW: | 774.93 | | EINECS: | | | Product Categories: | | | Mol File: | 2169967-47-7.mol |  |
| | MPEG16-Propyne Chemical Properties |
| | MPEG16-Propyne Usage And Synthesis |
| Uses | Propargyl-PEG17-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG17-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | Propargyl-PEG17-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | MPEG16-Propyne Preparation Products And Raw materials |
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