|
|
| | 2,6-Dichloro-4-iodophenol Basic information |
| Product Name: | 2,6-Dichloro-4-iodophenol | | Synonyms: | Phenol, 2,6-dichloro-4-iodo-;2,6-Dichloro-4-iodophenol;2,6-Dichloro-4-iodophenol 98%;2,6-dichloro-4-iodobenzenephenol | | CAS: | 34074-22-1 | | MF: | C6H3Cl2IO | | MW: | 288.9 | | EINECS: | | | Product Categories: | | | Mol File: | 34074-22-1.mol |  |
| | 2,6-Dichloro-4-iodophenol Chemical Properties |
| Melting point | 91-92 °C | | Boiling point | 278.2±40.0 °C(Predicted) | | density | 2.158±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 6.42±0.23(Predicted) | | Appearance | White to off-white Solid |
| | 2,6-Dichloro-4-iodophenol Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,6-dichloro-4-iodophenol from 2,6-dichlorophenol was as follows: 2,6-dichlorophenol (10 g, 61.35 mmol, 1.00 eq.) and N-iodosuccinimide (NIS, 27.6 g, 245.33 mmol, 2.00 eq.) were dissolved in methanol (100 mL) and stirred at room temperature for 1 hour. After completion of the reaction, the mixture was concentrated under reduced pressure. The concentrated residue was redissolved in ethyl acetate (50 mL) and washed with saturated saline (3 x 30 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether (100%) as eluent to afford 2,6-dichloro-4-iodophenol (10.5 g, 59% yield) as a yellow solid.1H-NMR (300 MHz, CDCl3): δ 9.83 (s, 1H), 7.27 (s, 2H) ppm. | | References | [1] Patent: WO2006/100026, 2006, A1. Location in patent: Page/Page column 121
[2] Synthetic Communications, 2014, vol. 44, # 14, p. 2094 - 2102
[3] Journal of the Brazilian Chemical Society, 2010, vol. 21, # 4, p. 770 - 774
[4] Synthetic Communications, 2012, vol. 42, # 16, p. 2407 - 2414
[5] Advanced Synthesis and Catalysis, 2013, vol. 355, # 14-15, p. 2936 - 2941 |
| | 2,6-Dichloro-4-iodophenol Preparation Products And Raw materials |
|