ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Suppliers list
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Products Intro: Product Name:B-Raf IN 1
CAS:950736-05-7
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CAS:950736-05-7
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CAS:950736-05-7
Purity:99.27% Package:1mg;50USD|5mg;118USD|10mg;208USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:BenzaMide,N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
CAS:950736-05-7
Purity:99% Package:1kg；25kg

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- manufacturers

  • B-Raf IN 1
  • B-Raf IN 1 pictures
  • $84.00 / 1mg
  • 2026-04-20
  • CAS:950736-05-7
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  • Purity: 99.50%
  • Supply Ability: 10g
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Basic information
Product Name:BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
Synonyms:BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-;B-Raf IN 1;CS-1184;RAF-IN-10n;MDK36057;N-(3-(3-(4-((diMethylaMino)Methyl)phenyl)pyrazolo[1,5-a]pyriMidin-7-yl)phenyl)-3-(trifluoroMethyl)benzaMide;B-Raf IN 1, >=98%;B-Raf inhibit 1
CAS:950736-05-7
MF:C29H24F3N5O
MW:515.53
EINECS:
Product Categories:Inhibitors
Mol File:950736-05-7.mol
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Structure
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Chemical Properties
density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 14 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
form Powder
pka12.75±0.70(Predicted)
color Light yellow to yellow
Safety Information
HS Code 2934999090
MSDS Information
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Usage And Synthesis
DescriptionB-RAF IN 1 is an inhibitor of B-RAF (IC50 = 24 nM) that also inhibits C-RAF (IC50 = 25 nM). It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα, at concentrations greater than 2 μM, but does inhibit p38α and CAMKII (IC50s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC50 values of 920 and 780 nM, respectively.
UsesN-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide is a potent and selective B-Raf inhibitor.
IC 50B-Raf: 24 nM (IC50)
References[1] DAN M. BERGER . Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2009, 19 23: Pages 6519-6523. DOI: 10.1016/j.bmcl.2009.10.049
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Preparation Products And Raw materials
Tag:BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-(950736-05-7) Related Product Information
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