- BOC-GLU(OBZL)-OME
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- $1.00
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2020-01-19
- CAS:59279-58-2
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 100kg
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| | Boc-Glu(OBzl)-OMe Basic information |
| Product Name: | Boc-Glu(OBzl)-OMe | | Synonyms: | BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;BOC-L-GLUTAMIC ACID-GAMMA-BENZYL ALPHA-METHYL-DIESTER;Boc-L-Glutamic Acid 5-Benzyl 1-Methyl Ester;Boc-L-Glu(OBzl)-OMe;N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;Boc-L-glutamic acid γ-benzyl α-methyl ester;Boc-L-glutamicacid-benzyla-methylester;BOC-L-GLUTAMIC ACID-Y-BENZYL A-METHYL-DIESTER | | CAS: | 59279-58-2 | | MF: | C18H25NO6 | | MW: | 351.39 | | EINECS: | | | Product Categories: | | | Mol File: | 59279-58-2.mol |  |
| | Boc-Glu(OBzl)-OMe Chemical Properties |
| Melting point | 38-41 °C | | Boiling point | 471.2±40.0 °C(Predicted) | | density | 1.144±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | pka | 10.96±0.46(Predicted) | | Appearance | White to light yellow Solid |
| | Boc-Glu(OBzl)-OMe Usage And Synthesis |
| Synthesis | Step 1: Iodomethane (1.01 mL, 16.3 mmol) was slowly added dropwise to a mixed solution of THF (14.82 mmol) and DMF (25 mL) of (2S)-5-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid (5.00 g) along with K2CO3 (2.25 g, 16.3 mmol). The reaction mixture was stirred at room temperature for about 3 hours before iodomethane (1.01 mL, 16.3 mmol) was added again. Subsequently, EtOAc was added to the reaction mixture and washed three times with 10% Na2S2O3 solution and then dried with MgSO4. After concentration under reduced pressure to remove the solvent, the crude product was purified by silica gel column chromatography (100:1, followed by 50:1 CHCl3/MeOH) to afford methyl (S)-5-benzyl-2-((tert-butoxycarbonyl)amino)pentanedioate (4.20 g, 12.23 mmol, 82% yield). m/z of C18H25NO6 was detected by ESIMS as 352 (M + H ). | | References | [1] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1899 - 1913
[2] Patent: US2008/318957, 2008, A1. Location in patent: Page/Page column 41-42
[3] Patent: WO2012/109164, 2012, A1. Location in patent: Page/Page column 39
[4] Organic and Biomolecular Chemistry, 2007, vol. 5, # 12, p. 1915 - 1923
[5] Organic Letters, 2016, vol. 18, # 9, p. 1968 - 1971 |
| | Boc-Glu(OBzl)-OMe Preparation Products And Raw materials |
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