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| | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Basic information | | Uses |
| Product Name: | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole | | Synonyms: | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole;5-bromo-1-methyl-1H-1,2,3-benzotriazole;1H-Benzotriazole, 5-bromo-1-methyl-;5-bromo-1-methyl-1,2,3-benzotriazole;5-Bromo-1-methylbenzo[d][1,2,3]triazole;5-Bromo-1-methylbenzotriazole | | CAS: | 944718-31-4 | | MF: | C7H6BrN3 | | MW: | 212.05 | | EINECS: | | | Product Categories: | | | Mol File: | 944718-31-4.mol | ![5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Structure](CAS/20150408/GIF/944718-31-4.gif) |
| | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Chemical Properties |
| Boiling point | 332.6±15.0 °C(Predicted) | | density | 1.76±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 0.40±0.30(Predicted) | | Appearance | Brown to reddish brown Solid |
| | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Usage And Synthesis |
| Uses | 5-Bromo-1-methyl-1H-benzo[D][1,2,3]triazole is an aromatic hydrocarbon derivative that can be used as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole from 4-bromo-N1-methylbenzene-1,2-diamine: 5-bromo-1-methyl-7H-benzo[2 (1.52 g, 22 mmol) was dissolved in water (5 ml) at 0 °C. The resulting solution was stirred at 0-10°C for 4 h. The pH was adjusted to 8 with potassium hydroxide (3N) and extracted with dichloromethane (2 x 200 ml). The organic layers were combined and concentrated in vacuum to give the residue. The residue was purified by silica gel chromatography (eluent: petroleum ether solution of 50% dichloromethane) to afford 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole as a red solid (1.5 g, 31% yield).LC/MS (ESI, m/z): [M + H]+ 213.1.1.1H-NMR (300 MHz, CDCl3) δ 8.24-8.25 (m, 1H), 7.60-7.63 (m, 1H), 7.42-7.46 (m, 1H), 4.32 (d, J = 5.4 Hz, 3H). | | References | [1] Patent: WO2012/119046, 2012, A2. Location in patent: Page/Page column 207-208 |
| | 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Preparation Products And Raw materials |
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