- 6-CYANONICOTINIC ACID
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- $1.10 / 1g
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2025-11-18
- CAS:70165-31-0
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 6-CYANONICOTINIC ACID
-
- $15.00 / 1KG
-
2021-07-13
- CAS:70165-31-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 6-CYANONICOTINIC ACID
-
- $15.00 / 1KG
-
2021-07-10
- CAS:70165-31-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 6-CYANONICOTINIC ACID Basic information |
| Product Name: | 6-CYANONICOTINIC ACID | | Synonyms: | 2-CYANO-5-CARBOXYPYRIDINE;6-CYANONICOTINIC ACID;6-CYANOPYRIDINE-3-CARBOXYLIC ACID;5-Carboxypicolinonitrile~2-Cyano-5-carboxypyridine~6-Cyanopyridine-3-carboxylic acid;5-carboxypicolinonitrile;6-Cyanonicotinic acid ,97%;3-Pyridinecarboxylicacid,6-cyano-(9CI);N-(Pyridin-3-ylmethyl)ethanamine | | CAS: | 70165-31-0 | | MF: | C7H4N2O2 | | MW: | 148.12 | | EINECS: | 626-716-9 | | Product Categories: | CARBOXYLICACID;NITRILE | | Mol File: | 70165-31-0.mol |  |
| | 6-CYANONICOTINIC ACID Chemical Properties |
| Melting point | 190-194 °C(lit.) | | Boiling point | 395.9±27.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in alcohol. | | form | Oil | | pka | 2.81±0.10(Predicted) | | color | Clear Yellow | | BRN | 4384027 | | InChI | 1S/C7H4N2O2/c8-3-6-2-1-5(4-9-6)7(10)11/h1-2,4H,(H,10,11) | | InChIKey | WMHSQCDPPJRWIL-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccc(nc1)C#N | | CAS DataBase Reference | 70165-31-0(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3439 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-CYANONICOTINIC ACID Usage And Synthesis |
| Uses | 6-Cyanonicotinic acid, is used in medicine | | Synthesis | The general procedure for the synthesis of 6-cyanonicotinic acid from oxonicotinic acid and sodium cyanide was as follows: to a 1.2 L DMF solution of oxonicotinic acid N-oxide (51 g, 0.37 mol) was added sodium cyanide (54 g, 1.1 mol), triethylamine (255 mL, 1.83 mol), and trimethylchlorosilane (185 mL). The reaction mixture was stirred at 110 °C for 10 h. After completion of the reaction, filtration was performed and the filtrate was concentrated. The residue was dissolved in 100 mL of 2N hydrochloric acid and extracted with dichloromethane. The organic layers were combined, concentrated and recrystallized from water to give 12 g (22% yield) of 6-cyanonicotinic acid. | | References | [1] Synthesis, 1983, # 4, p. 316 - 319
[2] Chemical Communications, 2004, # 15, p. 1770 - 1771
[3] Patent: WO2003/101956, 2003, A1. Location in patent: Page 113; 114
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 4, p. 385 - 389 |
| | 6-CYANONICOTINIC ACID Preparation Products And Raw materials |
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