| Company Name: |
SunaTech Inc. |
| Tel: |
0512-62872180 18994314770 |
| Email: |
sales@sunatech.com |
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| Product Name: | ECK | | Synonyms: | Myk2;Sek;ECK;EPHA2 (561-end), active, GST tagged human;ANTI-MOUSE EPHA2 (CENTER) antibody produced in rabbit;Epha2;Ephrin type-A receptor 2;ANTI-MOUSE EPHA4 (CENTER) antibody produced in rabbit | | CAS: | 853787-75-4 | | MF: | C24H18O6S3 | | MW: | 498.59 | | EINECS: | | | Product Categories: | | | Mol File: | 853787-75-4.mol |  |
| Boiling point | 665.1±55.0 °C(Predicted) | | density | 1.464±0.06 g/cm3(Predicted) | | storage temp. | -70°C | | form | buffered aqueous solution | | biological source | rabbit | | Specific Activity | 74-102nmol/min·mg |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| Uses | EPHA2 (ephrin receptor A2) belongs to the Eph family of receptor tyrosine kinases. It is a type I transmembrane protein, and its exoplasmic domain consists of a ligand binding domain in its N-terminal, a cysteine-rich domain, and two fibronectin type III repeats. Its cytoplasmic domain contains a juxtamembrane region, a tyrosine kinase domain, a SAM (sterile-α-motif) motif, and a PDZ-binding domain. | | Biological Activity | EPHA2 binds to the ephrin-A ligand and has diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process can be reversed by ligation of EPHA2. |
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