Dde Biotin-PEG4-DBCO manufacturers
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| | Dde Biotin-PEG4-DBCO Basic information |
| | Dde Biotin-PEG4-DBCO Chemical Properties |
| Boiling point | 1103.9±65.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | 13.90±0.40(Predicted) | | form | Solid |
| | Dde Biotin-PEG4-DBCO Usage And Synthesis |
| Description | Dde Biotin-PEG4-DBCO is a cleavable biotin reagent that is reactive with azide moiety via copper-free Click Chemistry. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine. | | Uses | Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Dde Biotin-PEG4-DBCO Preparation Products And Raw materials |
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