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| | S-acetyl-PEG4-t-butyl ester Basic information |
| Product Name: | S-acetyl-PEG4-t-butyl ester | | Synonyms: | S-acetyl-PEG4-t-butyl ester;S-acetyl-dPEG5-t-boc;S-acetyl-PEG4-Boc;4,7,10,13-Tetraoxa-16-thiaoctadecanoic acid, 17-oxo-, 1,1-dimethylethyl ester;tert-butyl 2-oxo-6,9,12,15-tetraoxa-3-thiaoctadecan-18-oate;AcS-PEG4-COOtBu | | CAS: | 1818294-26-6 | | MF: | C17H32O7S | | MW: | 380.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1818294-26-6.mol |  |
| | S-acetyl-PEG4-t-butyl ester Chemical Properties |
| form | Liquid | | color | Brown to reddish brown |
| | S-acetyl-PEG4-t-butyl ester Usage And Synthesis |
| Description | S-acetyl-PEG4-t-butyl ester is a PEG linker containing a sulfur acetyl group and a t-butyl ester. The sulfur acetyl group can be deprotected to form a thiol group. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | | Uses | S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | S-acetyl-PEG4-t-butyl ester Preparation Products And Raw materials |
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