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| | 3'-Chloromethylacetophenone Basic information |
| Product Name: | 3'-Chloromethylacetophenone | | Synonyms: | Ethanone, 1-[3-(chloromethyl)phenyl]-;1-[3-(chloroMethyl)phenyl]ethan-1-one;1-(3-(chloroMethyl)phenyl)ethanone;SKL141;3′-Chloromethylacetophenone, CAS 41908-12-7;3'-Chloromethylacetophenone | | CAS: | 41908-12-7 | | MF: | C9H9ClO | | MW: | 168.62 | | EINECS: | | | Product Categories: | | | Mol File: | 41908-12-7.mol |  |
| | 3'-Chloromethylacetophenone Chemical Properties |
| Boiling point | 130-131 °C(Press: 7 Torr) | | density | 1.134±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | 3'-Chloromethylacetophenone Usage And Synthesis |
| Synthesis | At 0°C, 4 g (23.4 mmol) of 3-(chloromethyl)benzoic acid was dissolved in 250 g of anhydrous ether. Subsequently, 30 ml of lithium methyl solution was slowly added dropwise to this solution. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 30 minutes. Upon completion of the reaction, the reaction was quenched by the slow addition of water and the mixture was acidified with hydrochloric acid. The organic phase was separated, washed several times with water and dried with anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate:heptane (5:95, v/v). Finally, 2.7 g of 3'-chloromethylacetophenone was obtained in 69% yield. The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.62 (3H, s), 4.63 (2H, s), 7.44-7.50 (1H, t), 7.59-7.62 (1H, d, J = 7.6 Hz), 7.89-7.93 (1H, d, J = 6.5 Hz), 7.97 (1H, s). | | References | [1] Patent: US6689922, 2004, B1. Location in patent: Page column 20-21 |
| | 3'-Chloromethylacetophenone Preparation Products And Raw materials |
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