3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione manufacturers
- Lenalidomide-4-OH
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- $0.00 / 100mg
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2026-04-22
- CAS:1061604-41-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Basic information |
| Product Name: | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione | | Synonyms: | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione;3-(4-Hydroxy-1-oxo-isoindolin-2-yl)piperidine-2,6-dione;Lenalidomide-4-OH;2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-;3-(4-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)pi
peridine-2,6-dione;Benzoylchloride,4-chloro-4-fluoro-;3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-Hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dionl | | CAS: | 1061604-41-8 | | MF: | C13H12N2O4 | | MW: | 260.24538 | | EINECS: | | | Product Categories: | | | Mol File: | 1061604-41-8.mol |  |
| | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties |
| Boiling point | 602.9±55.0 °C(Predicted) | | density | 1.498±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | Solid | | pka | 8.86±0.20(Predicted) | | color | White to light brown | | InChI | InChI=1S/C13H12N2O4/c16-10-3-1-2-7-8(10)6-15(13(7)19)9-4-5-11(17)14-12(9)18/h1-3,9,16H,4-6H2,(H,14,17,18) | | InChIKey | HGPRKOYQOBYISD-UHFFFAOYSA-N | | SMILES | N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3O)C1=O |
| | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Usage And Synthesis |
| Uses | Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC. | | IC 50 | Cereblon | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials |
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