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| | D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Basic information |
| Product Name: | D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID | | Synonyms: | (2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propionic acid;(2R)-2-azanyl-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;D-5-HYDROXYTRYPTOPHAN;(2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;(R)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;5-hydroxy-d-tryptopha;D-Tryptophan, 5-hydroxy- | | CAS: | 4350-07-6 | | MF: | C11H12N2O3 | | MW: | 220.22 | | EINECS: | | | Product Categories: | | | Mol File: | 4350-07-6.mol |  |
| | D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Chemical Properties |
| Melting point | 270C | | Boiling point | 520.6±50.0 °C(Predicted) | | density | 1.484±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | pka | 2.22±0.10(Predicted) |
| | D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Usage And Synthesis |
| Uses | D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3]. | | Definition | ChEBI: The D-enantiomer of 5-hydroxytryptophan. | | in vivo | D-5-Hydroxytryptophan (100, 320 mg/kg; ip; single dose) cannot induce backward walking behavior in mice, while L-5-Hydroxytryptophan can do it[3].
| | References | [1] J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22. DOI:10.1016/0006-2952(67)90088-3
[2] Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):129-32. PMID:3132733
[3] Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31(1):39-46. DOI:10.1254/jjp.31.39 |
| | D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Preparation Products And Raw materials |
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