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| | N-methyl-N'-(propargyl-PEG4)-Cy5 Basic information |
| Product Name: | N-methyl-N'-(propargyl-PEG4)-Cy5 | | Synonyms: | N-methyl-N'-(propargyl-PEG4)-Cy5;2-(5-(3,3-dimethyl-1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)indolin-2-ylidene)penta-1,3-dien-1-yl)-1,3,3-trimethyl-3H-indol-1-ium chloride | | CAS: | 2107273-04-9 | | MF: | C37H47ClN2O4 | | MW: | 619.24 | | EINECS: | | | Product Categories: | | | Mol File: | 2107273-04-9.mol |  |
| | N-methyl-N'-(propargyl-PEG4)-Cy5 Chemical Properties |
| solubility | Soluble in DMSO, DMF, DCM, low solubility in water |
| | N-methyl-N'-(propargyl-PEG4)-Cy5 Usage And Synthesis |
| Description | N-methyl-N'-(propargyl-PEG4)-Cy5 is a cyanine linker with excitation/emmission maximum 649/667 nm containing an alkyne group, which enables Click Chemistry to attach deeply colored and photostable Cyanine fluorophore to various molecules. | | Uses | N-methyl-N'-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-methyl-N'-(propargyl-PEG4)-Cy5 Preparation Products And Raw materials |
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