Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate manufacturers
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| | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Basic information |
| Product Name: | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate | | Synonyms: | ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE;AURORA KA-3793;1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester;1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester;4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester;3-Pyridinecarboxylic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester (9CI, ACI) | | CAS: | 10350-10-4 | | MF: | C9H11NO4 | | MW: | 197.19 | | EINECS: | | | Product Categories: | New Products for Chemical Synthesis;Pyridines;Building Blocks;C9;Chemical Synthesis;Heterocyclic Building Blocks | | Mol File: | 10350-10-4.mol |  |
| | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Chemical Properties |
| Melting point | 216-222°C | | Boiling point | 362.9±42.0 °C(Predicted) | | density | 1.308±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.50±1.00(Predicted) | | Appearance | White to light yellow Solid |
| | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Usage And Synthesis |
| Uses | Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties. | | Synthesis | The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at the same temperature for 24 hours. After completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of alkaline activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2~3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%). | | References | [1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765 |
| | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Preparation Products And Raw materials |
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