- Cetrimide
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- $10.00 / 1kg
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2025-12-11
- CAS:1119-97-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10 mt
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| | Tetradecyltrimethylammonium bromide Chemical Properties |
| Melting point | 245-250 °C(lit.) | | density | 1.1328 (rough estimate) | | bulk density | 600kg/m3 | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.5260 (estimate) | | storage temp. | Store below +30°C. | | solubility | DMF: 2 mg/ml DMSO: 16 mg/ml Ethanol: 33 mg/ml PBS (pH 7.2): 5 mg/ml | | form | Fine Crystalline Powder | | color | White | | PH | pH (50g/l, 25℃ : 4.0～6.0 | | Water Solubility | H2O:10%(w/v) 20 g/100 mL | | λmax | λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02 | | Sensitive | Hygroscopic | | Merck | 14,6336 | | BRN | 3633227 | | Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents. | | Cosmetics Ingredients Functions | PRESERVATIVE | | InChIKey | CXRFDZFCGOPDTD-UHFFFAOYSA-M | | LogP | 2.2 at 20℃ | | CAS DataBase Reference | 1119-97-7(CAS DataBase Reference) | | EPA Substance Registry System | Tetradecyl trimethyl ammonium bromide (1119-97-7) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45-27 | | RIDADR | UN 3263 8/PG 2 | | WGK Germany | 3 | | RTECS | BS5776000 | | F | 3 | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29239000 | | Toxicity | LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl) |
| | Tetradecyltrimethylammonium bromide Usage And Synthesis |
| Physical properties | Cetrimide is a white fine powder crystal with a melting point of 245°C
to 250°C. A rough estimate of its density is 1.1328. It is soluble in
water with a solubility of 20 g/100 mL. | | Description | MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4 | | Uses | Disinfectant; deodorant; laboratory reagent. | | Uses | Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis. | | Definition | Myristyltrimethylammonium bromide is an organic molecular entity. | | General Description | Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant. | | Purification Methods | Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.] | | References | 1) ANNIE QUAN. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.[J]. Molecular Pharmacology, 2007, 72 6: 1425-1439. DOI:10.1124/mol.107.034207.
2) SAMIR VYAS. Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high-performance liquid chromatography.[J]. Journal of Pharmacy and Bioallied Sciences, 2011, 3 2: 310-314. DOI:10.4103/0975-7406.80766.
3) SIMON DE BECO. Endocytosis is required for E-cadherin redistribution at mature adherens junctions.[J]. ACS Catalysis , 2009: 7010-7015. DOI:10.1073/pnas.0811253106.
4) YOON HEE KIM . Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells[J]. Biochemical and biophysical research communications, 2016, 478 4: Pages 1609-1616. DOI:10.1016/j.bbrc.2016.08.165. |
| | Tetradecyltrimethylammonium bromide Preparation Products And Raw materials |
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