3-Azidopropanoic acid NHS ester manufacturers
- N3-C2-NHS ester
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2025-06-07
- CAS:850180-76-6
- Min. Order: 250mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | 3-Azidopropanoic acid NHS ester Basic information |
| Product Name: | 3-Azidopropanoic acid NHS ester | | Synonyms: | 3-azidopropanoate-N-hydroxysuccinimide ester;3-Azidopropanoic acid NHS ester;(2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate;N3-C2-NHS ester;(2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate - [A19129] | | CAS: | 850180-76-6 | | MF: | C7H8N4O4 | | MW: | 212.17 | | EINECS: | | | Product Categories: | | | Mol File: | 850180-76-6.mol |  |
| | 3-Azidopropanoic acid NHS ester Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF | | form | Oil | | color | Colorless to off-white |
| | 3-Azidopropanoic acid NHS ester Usage And Synthesis |
| Description | 3-Azidopropanoic acid NHS ester is an azidopropanoic acid linker that contains an NHS ester group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne, DBCO and BCN. The NHS ester can react with other primary amines to label proteins and antibodies. | | Uses | N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Non-cleavable Linker | | References | [1] Gregson SJ, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736 |
| | 3-Azidopropanoic acid NHS ester Preparation Products And Raw materials |
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