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| | Hydroxy-Amino-bis(PEG2-propargyl) Basic information |
| | Hydroxy-Amino-bis(PEG2-propargyl) Chemical Properties |
| Boiling point | 412.1±40.0 °C(Predicted) | | density | 1.079±0.06 g/cm3(Predicted) | | pka | 14.69±0.10(Predicted) |
| | Hydroxy-Amino-bis(PEG2-propargyl) Usage And Synthesis |
| Description | Hydroxy-Amino-bis(PEG2-propargyl) is a 3-arm linker with a terminal hydroxy group and two propargyl groups. The propargyl groups can participate in copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | | Uses | Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Hydroxy-Amino-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Hydroxy-Amino-bis(PEG2-propargyl) Preparation Products And Raw materials |
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