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| | N-Me-N-(PEG2-propargyl)2 Basic information |
| Product Name: | N-Me-N-(PEG2-propargyl)2 | | Synonyms: | N-Me-N-(PEG2-propargyl)2;N-methyl-2-(2-prop-2-ynoxyethoxy)-N-[2-(2-prop-2-ynoxyethoxy)ethyl]ethanamine;Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]- | | CAS: | 1835759-84-6 | | MF: | C15H25NO4 | | MW: | 283.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-84-6.mol |  |
| | N-Me-N-(PEG2-propargyl)2 Chemical Properties |
| Boiling point | 353.6±37.0 °C(Predicted) | | density | 1.025±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 7.83±0.50(Predicted) |
| | N-Me-N-(PEG2-propargyl)2 Usage And Synthesis |
| Description | N-Me-N-bis(PEG2-propargyl) has two alkyne groups which can participate in Click Chemistry reactions with azide-bearing compounds or biomolecules; copper is required for catalyzation. | | Uses | N-Me-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Me-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Me-N-(PEG2-propargyl)2 Preparation Products And Raw materials |
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