N-Boc-N-bis(PEG3-OH)
| 中文名称 | N-Boc-N-bis(PEG3-OH) |
|---|---|
| 中文同义词 | N-叔丁氧羰基-N-双(三聚乙二醇-羟基);N-叔丁氧羰基-N-BIS(三聚乙二醇-羟基);13-羟基-2-[2-[2-[2-[2-(2-羟基乙氧基)乙氧基]乙氧基]乙基]-5,8,11-三氧杂-2-氮杂十三烷酸叔丁酯;N-叔丁氧羰基-N-(三聚乙二醇-羟基)2;双(2-(2-(2-(2-羟基乙氧基)乙氧基)乙氧基)乙基)氨基甲酸叔丁酯;化合物 N-Boc-N-bis(PEG4-OH) |
| 英文名称 | N-Boc-N-bis(PEG3-OH) |
| 英文同义词 | N-Boc-N-(PEG3-OH)2;N-Boc-N-bis(PEG3-OH);5,8,11-Trioxa-2-azatridecanoic acid, 13-hydroxy-2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester;BocN-(PEG4-OH)2;tert-Butyl bis(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate |
| CAS号 | 2093154-01-7 |
| 分子式 | C21H43NO10 |
| 分子量 | 469.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2093154-01-7.mol |
| 结构式 |  |
N-Boc-N-bis(PEG3-OH) 性质
| 沸点 | 557.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.120±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 14.06±0.10(Predicted) |
N-Boc-N-bis(PEG4-OH) 是一种 PROTAC 连接桥，属于 PEG 类。N-Boc-N-bis(PEG4-OH) 可用于合成一系列 PROTAC 分子。N-Boc-N-bis(PEG4-OH) 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Cleavable
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PEGs
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Alkyl/ether
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.