N-叔丁氧羰基二乙胺
| 中文名称 | N-叔丁氧羰基二乙胺 |
|---|---|
| 中文同义词 | BOC-二乙醇胺;二(2-羟乙基)氨基甲酸叔丁酯;N-叔丁氧羰基二乙胺 1G;N-BOC-二乙醇胺;N-叔丁氧羰基二乙胺;N-叔丁氧羰基二乙醇胺;N-叔丁氧羰基二乙胺/N-BOC-二乙醇胺;N,N-双(2-羟乙基)氨基甲酸叔丁酯 |
| 英文名称 | TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE |
| 英文同义词 | TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE;BOC-DIETHANOLAMINE;Bis(2-hydroxyethyl)amine, N-BOC protected;N-Boc-diethanolamine >=98.0% (GC);1-Boc-diethanolamine;tert-Butyl bis(2-hydroxyethyl);CarbaMic acid, bis(2-hydroxyethyl)-, 1,1-diMethylethyl ester;Boc-diethanolamine≥ 98% (Assay) |
| CAS号 | 103898-11-9 |
| 分子式 | C9H19NO4 |
| 分子量 | 205.25 |
| EINECS号 | |
| 相关类别 | 其它;化工原料 |
| Mol文件 | 103898-11-9.mol |
| 结构式 |  |
N-叔丁氧羰基二乙胺 性质
| 沸点 | 324.2±35.0 °C(Predicted) |
|---|---|
| 密度 | 1.085 g/mL at 20 °C(lit.) |
| 折射率 | n |
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 酸度系数(pKa) | 14.29±0.10(Predicted) |
| 形态 | 液体或油 |
| 颜色 | 无色 |
| BRN | 4386562 |
| InChI | InChI=1S/C9H19NO4/c1-9(2,3)14-8(13)10(4-6-11)5-7-12/h11-12H,4-7H2,1-3H3 |
| InChIKey | KMUNFRBJXIEULW-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)N(CCO)CCO |
| CAS 数据库 | 103898-11-9 |
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Cleavable
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Alkyl/ether
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
24424-99-5
111-42-2
103898-11-9
在氮气保护下，将2,2'-氮杂二乙醇（4.21 g，40 mmol）溶于乙腈（50 mL）中，缓慢加入二碳酸二叔丁酯（Boc2O，9.60 g，44 mmol）的乙腈（50 mL）溶液。反应混合物在室温下搅拌3.5小时后，通过减压浓缩除去溶剂，得到二(2-羟乙基)氨基甲酸叔丁酯，产物为无色油状物（8.20 g，产率100%）。
参考文献：
[1] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 24, p. 3135 - 3138
[2] Nucleosides and Nucleotides, 1999, vol. 18, # 2, p. 227 - 238
[3] Nucleosides, Nucleotides and Nucleic Acids, 2002, vol. 21, # 2, p. 111 - 123
[4] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 17, p. 4645 - 4665
[5] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00384
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-W044078 | N-叔丁氧羰基二乙胺 N-Boc-diethanolamine | 103898-11-9 | 5 g | 100元 |
| 2026/06/05 | HY-W044078 | N-叔丁氧羰基二乙胺 N-Boc-diethanolamine | 103898-11-9 | 10 g | 150元 |