- Seclidemstat
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- $41.00
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2026-07-14
- CAS:1423715-37-0
- Purity: 98.28%
- Supply Ability: 10g
- Seclidemstat
-
-
2024-04-12
- CAS:1423715-37-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
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| | Seclidemstat Basic information |
| Product Name: | Seclidemstat | | Synonyms: | Seclidemstat;SP 2577;SP-2577;SP-2577;SP2577;SP 2577;Seclidemstat(SP-2577);Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide;(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide;SP2577,Inhibitor,replication,reversible,SWI/SNF,SP 2577,complex,Seclidemstat,antitumor,Ewing,Histone Demethylase,DNA,inhibit,immunity,Sarcoma | | CAS: | 1423715-37-0 | | MF: | C20H23ClN4O4S | | MW: | 450.94 | | EINECS: | | | Product Categories: | API | | Mol File: | 1423715-37-0.mol |  |
| | Seclidemstat Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (221.76 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 7.96±0.43(Predicted) | | color | Off-white to yellow |
| | Seclidemstat Usage And Synthesis |
| Uses | Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma[1][2]. | | IC 50 | KDM1/LSD1 | | References | [1] Dai XJ, et al. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1 [published correction appears in J Med Chem. 2021 May 13;64(9):6410-6411]. J Med Chem. 2021;64(5):2466-2488. DOI:10.1021/acs.jmedchem.0c02176
[2] Soldi R, et al. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One. 2020;15(7):e0235705. Published 2020 Jul 10. DOI:10.1371/journal.pone.0235705 |
| | Seclidemstat Preparation Products And Raw materials |
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