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| | 3-(4-Nitrophenyl)-beta-alanine Basic information |
| Product Name: | 3-(4-Nitrophenyl)-beta-alanine | | Synonyms: | RARECHEM AK HD C007;3-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID;3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID;3-(P-NITROPHENYL)-DL-BETA-ALANINE;DL-3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID;3-(4-Nitrophenyl)-beta-alanine;(RS)-3-Amino-3-(4-nitrophenyl)-propionic acid;DL-3-Amino-3-(4-nitrophenyl)propanoic acid | | CAS: | 102308-62-3 | | MF: | C9H10N2O4 | | MW: | 210.19 | | EINECS: | | | Product Categories: | B-Amino;API intermediates | | Mol File: | 102308-62-3.mol |  |
| | 3-(4-Nitrophenyl)-beta-alanine Chemical Properties |
| Melting point | 226 °C (decomp) | | Boiling point | 410.3±40.0 °C(Predicted) | | density | 1.404±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.50±0.10(Predicted) | | Appearance | White to light yellow Solid | | CAS DataBase Reference | 102308-62-3(CAS DataBase Reference) |
| | 3-(4-Nitrophenyl)-beta-alanine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-amino-3-(4-nitrophenyl)propionic acid from malonic acid and p-nitrobenzaldehyde: A mixture of 2.40 g of p-nitrobenzaldehyde, 2.44 g of malonic acid, and 3.54 g of ammonium acetate (molar ratio 1:1.1:2.3) was dissolved in 200 mL of 1 -butanol, and the reaction was carried out at reflux for 1.5-2 hr until the release of carbon dioxide gas stopped. Upon completion of the reaction, the precipitate formed was filtered and washed sequentially with boiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and 100 mL of water. The precipitate was dried at 80-100°C for 8-10 hours. The purity of the product was checked by thin layer chromatography (TLC) and the reaction yield was about 65-80%. | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268 |
| | 3-(4-Nitrophenyl)-beta-alanine Preparation Products And Raw materials |
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