|
|
| | KATOYYZUTNAWSA-OIZRIKEUSA-N Basic information |
| Product Name: | KATOYYZUTNAWSA-OIZRIKEUSA-N | | Synonyms: | KATOYYZUTNAWSA-OIZRIKEUSA-N;5,7,11,14-Eicosatetraenoic acid, 9-hydroxy-, (5Z,7E,11Z,14Z)-;(5E,7E,10R,12E,14E)-10-hydroxyicosa-5,7,12,14-tetraenoic acid | | CAS: | 70968-92-2 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 70968-92-2.mol |  |
| | KATOYYZUTNAWSA-OIZRIKEUSA-N Chemical Properties |
| Boiling point | 487.676±33.00 °C(Press: 760.00 Torr)(predicted) | | density | 0.984±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | 0.1 M Na2CO3: 2 mg/ml
DMF: Miscible
DMSO: Miscible
Ethanol: MisciblePBS (pH 7.2): 0.8 mg/ml | | pka | 4.730±0.10(predicted) |
| | KATOYYZUTNAWSA-OIZRIKEUSA-N Usage And Synthesis |
| Uses | 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590)[1]. | | Definition | ChEBI: 9-HETE is an HETE that is (5Z,7E,11Z,14Z)-icosa-5,7,11,14-tetraenoic acid in which the hydroxy group is located at position 9. It has a role as a metabolite. It is a conjugate acid of a 9-HETE(1-). | | References | [1] Goetzl EJ, et al. Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. J Exp Med. 1979 Aug 1;150(2):406-11. DOI:10.1084/jem.150.2.406
[2] WILLIAM S. POWELL Joshua R. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 340-355. DOI: 10.1016/j.bbalip.2014.10.008
[3] JORGE CAPDEVILA . Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450[J]. Biochemical and biophysical research communications, 1986, 141 3: Pages 1007-1011. DOI: 10.1016/s0006-291x(86)80144-9
[4] MEHDI H. SHISHEHBOR . Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease[J]. Free Radical Biology and Medicine, 2006, 41 11: Pages 1678-1683. DOI: 10.1016/j.freeradbiomed.2006.09.001
[5] ZONGYUAN WU, FANG WEI* Analytical Strategy for Oxylipin Annotation by Combining Chemical Derivatization-Based Retention Index Algorithm and Feature Tandem Mass Spectrometric Fragmentation as a Biomarker Discovery Tool[J]. Analytical Chemistry, 2023, 95 43: 15933-15942. DOI: 10.1021/acs.analchem.3c02789
[6] YILIN PANG . LC−MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303 |
| | KATOYYZUTNAWSA-OIZRIKEUSA-N Preparation Products And Raw materials |
|