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| | 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information |
| | 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties |
| Melting point | 36-41°C | | Boiling point | 319.4±32.0 °C(Predicted) | | density | 1.056±0.06 g/cm3(Predicted) | | Fp | >198℃ | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 10.11±0.10(Predicted) | | form | low melting solid | | color | Light yellow to yellow | | InChI | InChI=1S/C11H23N3O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9,12H2,1-3H3 | | InChIKey | QSYTWBKZNNEKPN-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCN(CCN)CC1 | | CAS DataBase Reference | 192130-34-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis |
| Uses | tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a useful research chemical for the synthesis of biologically active compounds. | | Synthesis | GENERAL METHOD: N-substituted phthalimide (2.00 mmol) was mixed with 80% aqueous hydrazine hydrate (2 mL) in ethanol (20 mL) and the reaction was stirred at 70°C for 20 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove the precipitate. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product, which can be used directly in subsequent reactions without further purification. | | References | [1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 7, p. 2251 - 2259
[2] ChemMedChem, 2014, vol. 9, # 4, p. 752 - 761 |
| | 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials |
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