- 4-MUNANA
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- $31.00 / 1mg
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2026-01-05
- CAS:76204-02-9
- Min. Order:
- Purity: 99.58%
- Supply Ability: 10g
- Neu5Ac-a-4Mu
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- $0.00 / 5G
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2020-03-26
- CAS:76204-02-9
- Min. Order: 1G
- Purity: 97%HPLC
- Supply Ability: MG-KG
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| | (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Basic information |
| | (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Chemical Properties |
| Melting point | 171°C dec. | | storage temp. | −20°C | | solubility | H2O: 50 mg/mL, clear, very slightly yellow | | form | Solid | | color | White to Off-White | | Water Solubility | water: 50mg/mL, clear to slightly hazy, colorless to light yellow |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 3-10 | | HS Code | 29322090 |
| | (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Usage And Synthesis |
| Description | 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus. | | Chemical Properties | Off-White to Yellow Solid | | Uses | Used as a substrate in a fluorometric assay of neuraminidase. | | Uses | (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt has been used for fluorometric assay of neuraminidase as well as fluorescent staining of sialidases in PAGE. | | Biochem/physiol Actions | Substrate for fluorometric assay of neuraminidase. Used for fluorescent staining of sialidases in PAGE. | | References | [1] E MONTI. Expression of a novel human sialidase encoded by the NEU2 gene.[J]. Glycobiology, 1999, 9 12: 1313-1321. DOI: 10.1093/glycob/9.12.1313
[2] NICHOLAS M STAMATOS. Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.[J]. FEBS Journal, 2005, 272 10: 2545-2556. DOI: 10.1111/j.1742-4658.2005.04679.x
[3] ALAN S CROSS. NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.[J]. The Journal of Biological Chemistry, 2012: 15966-15980. DOI: 10.1074/jbc.m112.346817
[4] N T WETHERALL. Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network.[J]. Journal of Clinical Microbiology, 2003, 41 2: 742-750. DOI: 10.1128/jcm.41.2.742-750.2003 |
| | (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Preparation Products And Raw materials |
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