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| | 3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Basic information | | Uses |
| | 3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties |
| Melting point | 159-161 °C (lit.) | | Boiling point | 234.6±40.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 8.06±0.10(Predicted) | | form | Solid | | Appearance | White to off-white Solid | | InChI | 1S/C6H3ClF3NO/c7-4-1-3(6(8,9)10)2-11-5(4)12/h1-2H,(H,11,12) | | InChIKey | AJPOOWWMZOPUCG-UHFFFAOYSA-N | | SMILES | Oc1ncc(cc1Cl)C(F)(F)F | | CAS DataBase Reference | 76041-71-9(CAS DataBase Reference) |
| Hazard Codes | T,Xi | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-36/37-45 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis |
| Uses | 3-Chloro-5-(trifluoromethyl)pyridin-2(3H)-one is a useful research chemical. | | Chemical Properties | White to light yellow solid | | Synthesis | General procedure for the synthesis of 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine from 2-hydroxy-5-(trifluoromethyl)pyridine: 2-hydroxy-5-(trifluoromethyl)pyridine (15.3 g, 0.094 mol) and N-chlorosuccinimide (14.4 g, 0.108 mol) were dissolved in 50 mL of anhydrous N,N-dimethylformamide (DMF) and nitromethane in a in a mixed solvent. The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, the reaction solution was slowly poured into 250 mL of water and a light yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 17.1 g (0.087 mol) of 3-chloro-5-trifluoromethyl-2-hydroxypyridine in 92% yield. | | References | [1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0025 |
| | 3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials |
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