| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
1,2-Benzisoxazole manufacturers
- 1,2-benzoxazole
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2022-01-18
- CAS:271-95-4
- Min. Order: 1KG
- Purity: 99.1%
- Supply Ability: 100 tons
- Indoxazene
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- $1.00
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2020-01-10
- CAS:271-95-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 200kgs
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| | 1,2-Benzisoxazole Chemical Properties |
| Melting point | 139 °C | | Boiling point | 90-92 °C15 mm Hg(lit.) | | density | 1.174 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.561(lit.) | | Fp | 86°C | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | pka | -2.03±0.30(Predicted) | | color | Colourless | | Water Solubility | Soluble in water. 4.1 mg/mL in water at 25°C | | Sensitive | Light Sensitive | | BRN | 2154 | | InChI | 1S/C7H5NO/c1-2-4-7-6(3-1)5-8-9-7/h1-5H | | InChIKey | KTZQTRPPVKQPFO-UHFFFAOYSA-N | | SMILES | c1ccc2oncc2c1 | | CAS DataBase Reference | 271-95-4(CAS DataBase Reference) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | F | 8 | | HS Code | 2934.99.4400 | | Storage Class | 10 - Combustible liquids |
| | 1,2-Benzisoxazole Usage And Synthesis |
| Synthesis | 1. Synthesis of (E)-2-hydroxybenzaldehyde oxime: Triethylamine (190 mmol) was slowly added to a solution of 2-hydroxybenzaldehyde (164 mmol) and hydroxylamine hydrochloride (197 mmol) in ethanol (200 mL), and the reaction mixture was heated at 95 °C for 5 h. The reaction mixture was concentrated, and the residue was extracted with ethyl acetate (2 × 150 mL) and water (100 mL). The combined organic layers were washed with water (3 × 150 mL), dried (magnesium sulfate), and concentrated. The residue was purified by rapid chromatography (1/100 ethyl acetate/petroleum ether) to provide (E)-2-hydroxybenzaldehyde oxime as a white solid in 43% yield. 2) Synthesis of 1,2-BENZISOXAZOLE: At 0 °C, over 4 hours, a solution of DEAD (23.0 mmol) in tetrahydrofuran (150 mL) was added to a solution of (E)-2-hydroxybenzaldehyde oxime (21.9 mmol) and triphenylphosphine (23.0 mmol) in tetrahydrofuran (300 mL). The reaction mixture was then stirred at 0 °C for another 60 minutes and concentrated. The residue was purified by rapid chromatography (1/100 ethyl acetate/petroleum ether) to give 1,2-BENZISOXAZOLE as a yellow oil in 66% yield. 
| | Uses | 1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase. It is used to produce 5-nitro-benzo[d]isoxazole. It is involved in manufacturing medicines ( antiepileptics and antipsychotics). | | Definition | ChEBI: A benzoxazole in which the benzene ring is fused to a 1,2-oxazole ring across positions 4 and 5. | | General Description | 1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase. |
| | 1,2-Benzisoxazole Preparation Products And Raw materials |
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