3-Boc-aminomethylpyrrolidine manufacturers
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| | 3-Boc-aminomethylpyrrolidine Basic information |
| Product Name: | 3-Boc-aminomethylpyrrolidine | | Synonyms: | PYRROLIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER;3-(BOC-AMINOMETHYL)PYRROLIDINE;(3-PYRROLIDINYLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;3-N-BOC-AMINOMETHYL PYRROLIDINE;3-(tert-Butoxycarbonylaminomethyl)pyrrolidine;3-BOCAMINOMETHYLPYRROLIDINE 98%;Carbamic acid, N-(3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester;3-(Boc-aminomethyl)pyrrol... | | CAS: | 149366-79-0 | | MF: | C10H20N2O2 | | MW: | 200.28 | | EINECS: | | | Product Categories: | pharmacetical;Pyrrole&Pyrrolidine&Pyrroline | | Mol File: | 149366-79-0.mol |  |
| | 3-Boc-aminomethylpyrrolidine Chemical Properties |
| Boiling point | 303.9±15.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 12.71±0.46(Predicted) | | form | gel/ oil | | color | Yellow | | InChI | InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-7-8-4-5-11-6-8/h8,11H,4-7H2,1-3H3,(H,12,13) | | InChIKey | WIEJVMZWPIUWHO-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)NCC1CCNC1 | | CAS DataBase Reference | 149366-79-0(CAS DataBase Reference) |
| | 3-Boc-aminomethylpyrrolidine Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-Boc-aminomethylpyrrolidine from the compound (CAS:172477-98-4) is as follows:
Example 10: Preparation of N-methyl-6-{[2-({3-[(methylamino)methyl]pyrrolidin-1-yl}carbonyl)thieno[3,2-b]pyridin-7-yl]oxy}-1-naphthalenecarboxamide
A. Preparation of Intermediate 10a.
To a solution of tert-butyl (1-benzylpyrrolidin-3-yl)methylcarbamate (3.0 g, 10.33 mmol) in EtOAc (100 mL) was added Pd(OH)2/C (0.3 g). The mixture was stirred at room temperature under H2 atmosphere for 3 h. After completion of the reaction, it was filtered through diatomaceous earth. The filtrate was concentrated to give a colorless oily product (1.87 g, 90% yield), which could be used in the next reaction without further purification. | | References | [1] Patent: WO2005/21553, 2005, A1. Location in patent: Page/Page column 54-55 |
| | 3-Boc-aminomethylpyrrolidine Preparation Products And Raw materials |
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