2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole Suppliers list

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole manufacturers

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole Basic information

Product Name:	2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole
Synonyms:	HEXAHYDRO-PYRROLO[3,4-C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE HYDROCHLORIDE;2-Boc-hexahydro-pyrrpol[3,4-c]pyrrole;Pyrrolo[3,4-c]Pyrrole-2(1H)-Ca;2-Boc-octahydropyrrolo[3,4-c]pyrrole;4-c]pyrrole-2(1H)-carboxylate;tert-butyl hexahydropyrrolo[3;2-Boc-hexahydro-pyrrpol[3...
CAS:	141449-85-6
MF:	C11H20N2O2
MW:	212.29
EINECS:
Product Categories:	Amines and Anilines;Heterocycles
Mol File:	141449-85-6.mol

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole Chemical Properties

Boiling point	295.4±33.0 °C(Predicted)
density	1.076±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	10.72±0.20(Predicted)
form	solid
color	White to off-white

Safety Information

HS Code

2933998090

MSDS Information

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole Usage And Synthesis

Uses	2-Boc-Hexahydro-pyrrolo[3,4-C]pyrrole is an organic synthetic intermediate compound used in the preparation of anticancer agent compounds and sigma-2 ligands.
Synthesis	186202-73-3 141449-85-6 Example 6C: Synthesis of tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate To a solution of tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (107.8 g, 0.356 mol), the product of Example 6B, in methanol (250 mL) was added wet 20% Pd(OH)2/C catalyst (10.8 g). The reaction mixture was hydrogenated for 2.5 hours at 50°C and 60 psi under a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the title compound tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (74 g, 0.35 mol, 98% yield). Mass spectrum (DCI/NH3) m/z: 213 ([M+H]+).
References	[1] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 22 [2] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 28 [3] Patent: WO2009/111550, 2009, A1. Location in patent: Page/Page column 37 [4] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00250 [5] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0371-0372

2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole Preparation Products And Raw materials

Raw materials	5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole-->Methanol-->Hydrogen
Preparation Products	JNJ-42847922-->Pyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-(3-methoxyphenyl)-, 1,1-dimethylethyl ester-->Pyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid, 5-(6-chloro-3-pyridazinyl)hexahydro-, 1,1-dimethylethyl ester

Tag:2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole(141449-85-6) Related Product Information

Hexahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester HEXAHYDRO-PYRROLO[3,2-B]PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Pyrrolo[3,4-b]pyrrole-5(1H)-carboxylic acid, hexahydro-, ethyl ester 2-Boc-6-oxo-2-azaspiro[3.4]octane 2-Boc-5-oxo-octahydro-isoindole hexahydrocyclopenta[c]pyrrol-5(1H)-one N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE (3aR,6aS)-benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester (Meso-3aR,5r,6aS)-tert-butyl 5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2-methyl-octahydrocyclopenta[c]pyrrol-5-one 2-methyl-octahydrocyclopenta[c]pyrrol-5-one cis-5-Benzyl-2-Boc-hexahydropyrrolo[3,4-c]pyrrole (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole,5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE