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| | 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE Basic information |
| Product Name: | 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE | | Synonyms: | HEXAHYDRO-PYRROLO[3,4-C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE;2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE HYDROCHLORIDE;2-Boc-hexahydro-pyrrpol[3,4-c]pyrrole;Pyrrolo[3,4-c]Pyrrole-2(1H)-Ca;2-Boc-octahydropyrrolo[3,4-c]pyrrole;4-c]pyrrole-2(1H)-carboxylate;tert-butyl hexahydropyrrolo[3 | | CAS: | 141449-85-6 | | MF: | C11H20N2O2 | | MW: | 212.29 | | EINECS: | | | Product Categories: | Amines and Anilines;Heterocycles | | Mol File: | 141449-85-6.mol | ![2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE Structure](CAS/GIF/141449-85-6.gif) |
| | 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE Chemical Properties |
| Boiling point | 295.4±33.0 °C(Predicted) | | density | 1.076±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 10.72±0.20(Predicted) | | form | solid | | color | White to off-white |
| | 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE Usage And Synthesis |
| Uses | 2-Boc-Hexahydro-pyrrolo[3,4-C]pyrrole is an organic synthetic intermediate compound used in the preparation of anticancer agent compounds and sigma-2 ligands. | | Synthesis | Example 6C: Synthesis of tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
To a solution of tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (107.8 g, 0.356 mol), the product of Example 6B, in methanol (250 mL) was added wet 20% Pd(OH)2/C catalyst (10.8 g). The reaction mixture was hydrogenated for 2.5 hours at 50°C and 60 psi under a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the title compound tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (74 g, 0.35 mol, 98% yield). Mass spectrum (DCI/NH3) m/z: 213 ([M+H]+). | | References | [1] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 22 [2] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 28 [3] Patent: WO2009/111550, 2009, A1. Location in patent: Page/Page column 37 [4] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00250 [5] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0371-0372 |
| | 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE Preparation Products And Raw materials |
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