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| | ACECLIDINE HYDROCHLORIDE Basic information |
| Product Name: | ACECLIDINE HYDROCHLORIDE | | Synonyms: | Acetate-3-quinuclidinol Hydrochloride;1-azabicyclo[2.2.2]octan-8-yl acetate hydrochloride;1-azabicyclo[2.2.2]octan-8-yl ethanoate hydrochloride;acetic acid quinuclidin-3-yl ester hydrochloride;1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride;3-Acetoxyquinuclidine hydrochloride, Aceclidine hydrochloride;3-acetoxyquinuclidinehydrochloride;3-quinuclidinol,acetate(ester),hydrochloride | | CAS: | 6109-70-2 | | MF: | C9H16ClNO2 | | MW: | 205.68 | | EINECS: | 228-071-5 | | Product Categories: | Pharmaceuticals;Heterocycles;Intermediates & Fine Chemicals;API | | Mol File: | 6109-70-2.mol |  |
| | ACECLIDINE HYDROCHLORIDE Chemical Properties |
| Melting point | 166°C | | storage temp. | -20°C Freezer | | solubility | H2O: ≥15mg/mL at ~60°C | | form | powder | | color | white to tan | | Water Solubility | H2O: ≥15mg/mL at~60°C | | Stability: | Moisture Sensitive | | InChI | InChI=1/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H | | InChIKey | LWWSARSTZGNKGV-UHFFFAOYNA-N | | SMILES | C1(OC(=O)C)CN2CC[C@]1([H])CC2.Cl |&1:9,r| |
| RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | WGK 3 | | RTECS | VD6198000 | | HS Code | 2933998090 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Oral |
| | ACECLIDINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White Crystalline Powder | | Uses | Aceclidine is a synthetic analogue of Arecoline, a natural cholinomimetic alkaloid. Aceclidine acts as an agonist at cholinergic receptors and has therapeutic use to reduce intraocular pressure in glaucoma. A parasympathomimetic drug with weak anticholinesterase activity. | | Uses | Glaucoma;Parasympatho- | | Biological Activity | Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.', 'Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.', 'Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist th at is effective in reducing intraocular pressure. | | in vivo | Aceclidine (1-10mg/kg, s.c.) hydrochloride reverses Hemicholinium-3 (HY-B2152) induces spatial learning and deficit in rats[4].
| | IC 50 | mAChR1; mAChR3 |
| | ACECLIDINE HYDROCHLORIDE Preparation Products And Raw materials |
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