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| | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione Basic information |
| Product Name: | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione | | Synonyms: | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione;1H-Purine-2,6-dione, 3,7-dihydro-8-[(2-hydroxyethyl)amino]-7-[(3-methoxyphenyl)methyl]-1,3-dimethyl-;8-[(2-Hydroxyethyl)amino]-7-(3-methoxybenzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;7030B-C5 | | CAS: | 370871-42-4 | | MF: | C17H21N5O4 | | MW: | 359.38 | | EINECS: | | | Product Categories: | | | Mol File: | 370871-42-4.mol | ![8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione Structure](CAS/20180723/GIF/370871-42-4.gif) |
| | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione Chemical Properties |
| Boiling point | 612.3±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | pka | 14.55±0.10(Predicted) |
| | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione Usage And Synthesis |
| Uses | 7030B-C5 is a PCSK9 inhibitor (IC50=1.61 μM). 7030B-C5 can significantly reduce plasma cholesterol and triglyceride (TG) levels in vivo and slow the progression of atherosclerosis. 7030B-C5 can be used in the study of cardiovascular diseases[1]. | | References | [1] Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. DOI:10.1038/s41392-023-01690-3 |
| | 8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione Preparation Products And Raw materials |
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