| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-AKT antibody produced in rabbit
Purity:affinity isolated antibody Package:100UG Remarks:SAB4500800-100UG
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| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
027-65317797 15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Human RAC1 Protein, GST Tag
Purity:>90% as determined by SDS-PAGE Package:50μg, 100μg
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:PAK1 Antibody
Package:100ul Remarks: 见优宁维官网
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| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:RAC1
Purity:> 99% Package:50ul/RMB 1138;100ul/RMB 1880;200ul/RMB 2900 Remarks:Cell migration inducing gene 5 protein; Cell migration-inducing gene 5 protein; MIG5; MIG 5
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| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
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| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:PAK1 antibody
Purity:99% Package:1支/RMB 1280
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| Product Name: | ANTI-AKT1 | | Synonyms: | PAK1 ANTIBODY;Anti-AKT1 antibody produced in rabbit;Anti-C-AKT antibody produced in rabbit;Anti-PKB antibody produced in rabbit;Anti-RAC-PK-α antibody produced in rabbit;Anti-RAC-α serine/threonine-protein kinase antibody produced in rabbit;Anti-8 hydroxy 2’ deoxyguanosine antibody;Monoclonal Anti-AKT pS473 antibody produced in mouse | | CAS: | 2210301-92-9 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | proteins | | Mol File: | Mol File | ![ANTI-AKT1 Structure]() |
| | ANTI-AKT1 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | WGK Germany | WGK 2 | | HS Code | 3504009000 | | Storage Class | 10 - Combustible liquids |
| | ANTI-AKT1 Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper) | | Uses | Anti-AKT1 (Ab-473) antibody has been used in western blotting and immunostaining. | | Uses | Anti-AKT antibody produced in rabbit has been used in Western Blotting. | | General Description | Anti-AKT Antibody detects endogenous levels of total AKT protein. | | Biochem/physiol Actions | AKT serine/threonine kinase 1 (AKT1) acts as a regulator of cell-survival and anti-apoptotic functions. This protein has a crucial role in tumorigenesis. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in AKT1 signaling leads to the development of schizophrenia. | | Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey;Guinea Pig | | Background | The p21-activated kinase family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, control of phagocyte NADPH oxidase, and growth factor-induced neurite outgrowth. Several mechanisms that induce PAK activity have been reported. Binding of Rac/Cdc42 to the CRIB domain near the amino terminus of PAK causes autophosphorylation and conformational changes in PAK. Phosphorylation of PAK1 at Thr423 by PDK induces activation of PAK1. Several autophosphorylation sites have been identified, including Ser199 and Ser204 of PAK1, and Ser192 and Ser197 of PAK2. Because the autophosphorylation sites are located in the amino-terminal inhibitory domain, it has been hypothesized that modification in this region prevents the kinase from reverting to an inactive conformation. Research indicates that phosphorylation at Ser144 of PAK1 or Ser139 of PAK3 affects kinase activity. Phosphorylation at Ser21 of PAK1 or Ser20 of PAK2 regulates binding with the adaptor protein Nck. PAK4, PAK5/7, and PAK6 have lower sequence similarity with PAK1-3 in the amino-terminal regulatory region. Phosphorylation at Ser474 of PAK4, a site analogous to Thr423 of PAK1, may play a pivotal role in regulating the activity and function of PAK4. PAK family members are widely expressed, and often overexpressed in human cancer. | | References | [1] Knaus, U.G. and Bokoch, G.M. (1998) Int. J. Biochem. Cell Biol. 30, 857-62.
[2] Daniels, R.H. et al. (1998) EMBO J. 17, 754-64.
[3] King, C.C. et al. (2000) J. Biol. Chem. 275, 41201-9.
[4] Manser, E. et al. (1997) Mol. Cell. Biol. 17, 1129-43.
[5] Gatti, A. et al. (1999) J. Biol. Chem. 274, 8022-8.
[6] Lei, M. et al. (2000) Cell 102, 387-97.
[7] Chong, C. et al. (2001) J. Biol. Chem. 276, 17347-53.
[8] Zhao, Z. et al. (2000) Mol. Cell. Biol. 20, 3906-17.
[9] Abo, A. et al. (1998) EMBO J. 17, 6527-640.
[10] Qu, J. et al. (2001) Mol. Cell. Biol. 21, 3523-33.
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| | ANTI-AKT1 Preparation Products And Raw materials |
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