IDH1 INHIBITOR 1
| 中文名称 | IDH1 INHIBITOR 1 |
|---|---|
| 中文同义词 | 化合物 T11613;化合物 IDH1 INHIBITOR 1 |
| 英文名称 | IDH1 Inhibitor 1 |
| 英文同义词 | IDH1 Inhibitor 1;2-Oxazolidinone, 4-(fluoromethyl)-3-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]-1H-imidazol-4-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)-;IDH-1 Inhibitor 1,IDH1 Inhibitor 1 |
| CAS号 | 2234285-81-3 |
| 分子式 | C20H18F4N6O2 |
| 分子量 | 450.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2234285-81-3.mol |
| 结构式 |  |
IDH1 INHIBITOR 1 性质
| 储存条件 | 4°C, away from moisture and light |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IDH1 Inhibitor 1 是一种有效的，口服生物可利用的，脑渗透性，选择性突变 IDH1 抑制剂，抑制 IDH1R132H，IDH1R132C，和 IDH1WT，IC50 分别为 0.021 μM, 0.045 μM, 和 2.52 μM。具有抗肿瘤活性。
IC50: 0.021 μM (IDH1 R132H ), 0.045 μM (IDH1 R132C ), and 2.52 μM (IDH1 WT )
IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1 R132H/+ with an IC 50 of 0.039 μM.
IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1 R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-112601 | IDH1 Inhibitor 1 | 2234285-81-3 | 1 mg | 3120元 |
| 2025/12/22 | HY-112601 | IDH1 INHIBITOR 1 IDH1 Inhibitor 1 | 2234285-81-3 | 10 mM * 1 mLin DMSO | 7729元 |