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| | TCO-PEG4-TCO Basic information |
| Product Name: | TCO-PEG4-TCO | | Synonyms: | TCO-PEG4-TCO;5,8,11,14-Tetraoxa-2,17-diazaoctadecanedioic acid, 1,18-di-4-cycloocten-1-yl ester | | CAS: | 2243569-23-3 | | MF: | C28H48N2O8 | | MW: | 540.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2243569-23-3.mol |  |
| | TCO-PEG4-TCO Chemical Properties |
| Boiling point | 661.4±55.0 °C(Predicted) | | density | 1.12±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.65±0.46(Predicted) |
| | TCO-PEG4-TCO Usage And Synthesis |
| Description | TCO-PEG4-TCO is a bifunctional click chemistry reagent with TCO moieties at both ends of the molecule. TCO group enable click chemistry with tetrazine. The hydrophilic PEG linker increases the solubility of compounds in aqueous media. | | Uses | TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
| | TCO-PEG4-TCO Preparation Products And Raw materials |
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