3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate

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3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Basic information
Product Name:3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate
Synonyms:3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate;NO2-SPP-sulfo-Me;Pentanoic acid, 4-[(5-nitro-2-pyridinyl)dithio]-, 3-(methylsulfonyl)-2,5-dioxo-1-pyrrolidinyl ester;3-(methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfaneyl)pentanoate
CAS:890409-87-7
MF:C15H17N3O8S3
MW:463.51
EINECS:
Product Categories:
Mol File:890409-87-7.mol
3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Structure
3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Chemical Properties
Boiling point 687.5±65.0 °C(Predicted)
density 1.59±0.1 g/cm3(Predicted)
pka-2.22±0.29(Predicted)
Safety Information
MSDS Information
3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Usage And Synthesis
UsesNO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC)[1].
IC 50Disulfide Cleavable Linker; Cleavable Linker
References[1] Robert J. Lutz, et al.Methods for decreasing ocular toxicity of antibody drug conjugates. WO2012138749A1.
3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Preparation Products And Raw materials
Tag:3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate(890409-87-7) Related Product Information
SNPB SNPB-sulfo-Me Pentanoic acid, 4-[(5-nitro-2-pyridinyl)dithio]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester Pentanoic acid, 4-methyl-4-[(5-nitro-2-pyridinyl)dithio]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester Butanoic acid, 4-[(5-nitro-2-pyridinyl)dithio]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester 2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate