2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate

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2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Basic information
Product Name:2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate
Synonyms:2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate;NO2-SPDMV
CAS:663598-98-9
MF:C15H17N3O6S2
MW:399.44
EINECS:
Product Categories:
Mol File:663598-98-9.mol
2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Structure
2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Chemical Properties
Boiling point 550.697±60.00 °C(Press: 760.00 Torr)(predicted)
density 1.473±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka-1.099±0.10(predicted)
Safety Information
MSDS Information
2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Usage And Synthesis
UsesNO2-SPDMV is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50Disulfide Cleavable Linker; Cleavable Linker
References[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Preparation Products And Raw materials
Tag:2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate(663598-98-9) Related Product Information
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