Pentafluorobenzenesulfonyl fluorescein manufacturers
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| | Pentafluorobenzenesulfonyl fluorescein Basic information |
| Product Name: | Pentafluorobenzenesulfonyl fluorescein | | Synonyms: | 6'-HYDROXY-3-OXASPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3'-YL ESTER, PENTAFLUOROBENZENESULFONIC ACID;UIBLLPHZQUTIBL-UHFFFAOYSA-N;Benzenesulfonic acid, 2,3,4,5,6-pentafluoro-, 6'-hydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl ester;Pentafluorobenzenesulfonyl;Pentafluorobenzenesulfonyl fluorescein | | CAS: | 728912-45-6 | | MF: | C26H11F5O7S | | MW: | 562.42 | | EINECS: | | | Product Categories: | | | Mol File: | 728912-45-6.mol |  |
| | Pentafluorobenzenesulfonyl fluorescein Chemical Properties |
| Boiling point | 707.286±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.781±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .25 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 9.185±0.20(predicted) | | color | Light yellow to yellow | | Appearance | Solid Powder |
| | Pentafluorobenzenesulfonyl fluorescein Usage And Synthesis |
| Description | Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.1 Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.1 | | Uses | Pentafluorobenzenesulfonyl fluorescein is a H2O2-selective sensor that can be used to detect H2O2 levels in cells. Pentafluorobenzenesulfonyl fluorescein is normally non-fluorescent but fluoresces upon perhydrolysis of the sulfonyl linkage by H2O2[1]. | | References | 1. Maeda, H., Fukuyasu, Y., Yoshida, S., et al. Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism Angew. Chem. Int. Ed. Engl. 43(18),2389-2391(2004). | | Excitation / Emission Maximum | 465-505 nm/505-555 nm |
| | Pentafluorobenzenesulfonyl fluorescein Preparation Products And Raw materials |
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