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| | RR-11a analog Basic information |
| Product Name: | RR-11a analog | | Synonyms: | RR-11a analog;L-Alanine, N-[(phenylmethoxy)carbonyl]-L-alanyl-, 2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-1,4-dioxo-2-buten-1-yl]hydrazide;Ethyl (E)-4-(1-(2-amino-2-oxoethyl)-2-(((benzyloxy)carbonyl)-L-alanyl-L-alanyl)hydrazinyl)-4-oxobut-2-enoate;RR-11a analog, 10 mM in DMSO;Phosphoglucose Isomerase, Rabbit muscle | | CAS: | 685543-66-2 | | MF: | C22H29N5O8 | | MW: | 491.5 | | EINECS: | | | Product Categories: | | | Mol File: | 685543-66-2.mol |  |
| | RR-11a analog Chemical Properties |
| density | 1.291±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (254.33 mM; Need ultrasonic) | | pka | 10.13±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | RR-11a analog Usage And Synthesis |
| Uses | RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2]. | | in vivo | RR-11a analog has a half-live of 3-10 min[2]. | | References | [1] Gtz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32. DOI:10.1021/jm701311r
[2] Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92. DOI:10.1021/jm049938j |
| | RR-11a analog Preparation Products And Raw materials |
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