TK05 manufacturers
- TK05
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- $1520.00
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2026-05-11
- CAS:1245734-61-5
- Purity:
- Supply Ability: 10g
- TK05
-
- $1520.00
-
2025-07-17
- CAS:1245734-61-5
- Purity:
- Supply Ability: 10g
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| Product Name: | TK05 | | Synonyms: | TK05;TK-05,TK05;Benzoic acid, 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-;5-[[5-[(4-Chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)benzoic acid | | CAS: | 1245734-61-5 | | MF: | C31H25ClN2O5 | | MW: | 540.99 | | EINECS: | | | Product Categories: | | | Mol File: | 1245734-61-5.mol |  |
| Boiling point | 769.1±60.0 °C(Predicted) | | density | 1.348±0.06 g/cm3(Predicted) | | solubility | DMSO: soluble
Methanol: soluble | | form | Solid | | pka | 2.56±0.36(Predicted) | | color | Light yellow to yellow |
| Uses | TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1]. | | Biological Activity | TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].
TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. | | in vivo | TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. | Animal Model: | Zymosan A induced peritonitis mouse model[1] | | Dosage: | 0.12 mg/kg; 6 mg/kg | | Administration: | Given i.p.; only once | | Result: | 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A. |
| | References | [1] Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16. |
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