1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-

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1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- manufacturers

  • Dooku1
  • Dooku1 pictures
  • $38.00
  • 2026-07-15
  • CAS:2253744-54-4
  • Purity: 99.74%
  • Supply Ability: 10g
  • Dooku1
  • Dooku1 pictures
  • $38.00
  • 2026-07-15
  • CAS:2253744-54-4
  • Purity: 99.74%
  • Supply Ability: 10g
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Basic information
Product Name:1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
Synonyms:1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-;Dooku1 (Yoda1 Analog);Inhibitor,Dooku 1,Dooku-1,Dooku1,inhibit;Dooku1, 10 mM in DMSO;Dooku1;SSGJ-707
CAS:2253744-54-4
MF:C13H9Cl2N3OS
MW:326.2
EINECS:
Product Categories:
Mol File:2253744-54-4.mol
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Structure
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Chemical Properties
Boiling point 526.5±60.0 °C(Predicted)
density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (383.20 mM)
pka13.56±0.50(Predicted)
form Solid
color White to off-white
InChI1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChIKeyMNPOBXLPCWFONX-UHFFFAOYSA-N
SMILESClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Usage And Synthesis
UsesDooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].
Biological ActivityDooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel th at inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.
in vivo

Dooku1 (10 μM incubate 20 min) selectively inhibits Yoda1-induced relaxation of aorta of wild-type male C57BL/6 mice[1].

Animal Model:wild-type male C57BL/6 mice’s aortic rings[1]
Dosage:10 μM
Administration:20 min
Result:Suppressed the Yoda1-induced relaxation.
storageStore at +4°C
References[1] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
[2] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Preparation Products And Raw materials
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