(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one

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(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Suppliers list
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CAS:2381037-82-5
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(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one manufacturers

  • RBN-2397
  • RBN-2397 pictures
  • $97.00
  • 2026-07-14
  • CAS:2381037-82-5
  • Purity: 99.90%
  • Supply Ability: 10g
  • RBN-2397
  • RBN-2397 pictures
  • $97.00
  • 2026-07-14
  • CAS:2381037-82-5
  • Purity: 99.90%
  • Supply Ability: 10g
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Basic information
Product Name:(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one
Synonyms:(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one;Cpd 561;3(2H)-Pyridazinone, 5-[[(1S)-1-methyl-2-[3-oxo-3-[4-[5-(trifluoromethyl)-2-pyrimidinyl]-1-piperazinyl]propoxy]ethyl]amino]-4-(trifluoromethyl)-;Atamparib (RBN-2397);4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one;RBM-2397;inhibit,carcinoma,Inhibitor,RBN-2397,NSCLC,RBN 2397,PARP,advanced,metastatic,squamous,cell,ovarian,poly ADP ribose polymerase,solid,RBN2397,tumor,lung;RNB-2397
CAS:2381037-82-5
MF:C20H23F6N7O3
MW:523.43
EINECS:
Product Categories:
Mol File:2381037-82-5.mol
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Structure
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Chemical Properties
density 1.53±0.1 g/cm3(Predicted)
solubility DMSO:200.0(Max Conc. mg/mL);382.1(Max Conc. mM)
form A crystalline solid
pka9.56±0.60(Predicted)
color White to off-white
InChIKeyUQZCQKXJAXKZQH-LBPRGKRZSA-N
SMILESC1(=O)NN=CC(N[C@@H](C)COCCC(=O)N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=C1C(F)(F)F
Safety Information
MSDS Information
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Usage And Synthesis
UsesRBN-2397 can be prepared as a PARP7 inhibitor, which is useful for treating cancer.
in vivo

RBN-2397 (oral administration; 3-100 mg/kg; once daily; 24-32 days) induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice[2].RBN-2397 (oral administration; 3-100 mg/kg; once daily; 32 days) causes complete regressions at the dose 100 mg/kg and exerts a dose-dependent effects on tumor growth at dose levels of ≥30 mg/kg[2].The half-life (t1/2) of RBN-2397 in vivo is 325 mins[2].

Animal Model:CB17 SCID mice with NCI-H1373 xenografts[2]
Dosage:3 mg/kg, 10mg/kg, 30 mg/kg, 100 mg/kg
Administration:Oral administration; once daily; 24-32 days
Result:Decreased tumor volume and exerted anti-tumor effects.
IC 50PARP-7: 3 nM (IC50); PARP-7: 1 nM (Kd)
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one Preparation Products And Raw materials
Tag:(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one(2381037-82-5) Related Product Information
DEMETON S 1-Piperazinecarboxamide, N-[4-[[1,6-dihydro-6-oxo-5-(trifluoromethyl)-4-pyridazinyl]amino]butyl]-4-[5-(trifluoromethyl)-2-pyrimidinyl]- (S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one