N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
| 中文名称 | N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE |
|---|---|
| 中文同义词 | 三肽抑制剂;化合物T38063;化合物 N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE |
| 英文名称 | N-Acetyl lysyltyrosylcysteine amide |
| 英文同义词 | N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC);L-Cysteinamide, N2-acetyl-L-lysyl-L-tyrosyl-;N-acetyl lysyltyrosylcysteine amide;Ac-Lys-Tyr-Cys-NH2;Ac-KYC-NH2 |
| CAS号 | 1287585-40-3 |
| 分子式 | C20H31N5O5S |
| 分子量 | 453.56 |
| EINECS号 | |
| 相关类别 | 科研试剂;目录肽 |
| Mol文件 | 1287585-40-3.mol |
| 结构式 |  |
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE 性质
| 沸点 | 902.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.273±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C, protect from light |
| 酸度系数(pKa) | 9.18±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChIKey | JTHKLTJLEVKKFW-ULQDDVLXSA-N |
| SMILES | C(N)(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCCN)NC(C)=O |
N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.
| Animal Model: | 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode) |
| Dosage: | 10 mg/kg |
| Administration: | I.p.; daily for 3-7 days |
| Result: | Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-125039 | N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE N-Acetyl lysyltyrosylcysteine amide | 1287585-40-3 | 1 mg | 900元 |
| 2026/06/05 | HY-125039 | N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE N-Acetyl lysyltyrosylcysteine amide | 1287585-40-3 | 5 mg | 2250元 |